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gene exp il4 mm00445259 m1  (Thermo Fisher)
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Thermo Fisher gene exp il4 mm00445259 m1
Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and <t>Il4</t> mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Gene Exp Il4 Mm00445259 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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il 4  (Sino Biological)
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Sino Biological il 4
Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and <t>Il4</t> mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Il 4, supplied by Sino Biological, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Average 95 stars, based on 1 article reviews
il 4 - by Bioz Stars, 2026-02
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gene exp il4 hs00174122 m1  (Thermo Fisher)
99
Thermo Fisher gene exp il4 hs00174122 m1
Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and <t>Il4</t> mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Gene Exp Il4 Hs00174122 M1, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/gene exp il4 hs00174122 m1/product/Thermo Fisher
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gene exp il4 hs00174122 m1 - by Bioz Stars, 2026-02
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anti human il4  (Miltenyi Biotec)
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Miltenyi Biotec anti human il4
Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and <t>Il4</t> mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Anti Human Il4, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse il 4 elisa 223 kit  (Proteintech)
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Proteintech mouse il 4 elisa 223 kit
Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and <t>Il4</t> mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Mouse Il 4 Elisa 223 Kit, supplied by Proteintech, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/mouse il 4 elisa 223 kit/product/Proteintech
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mouse il 4 elisa 223 kit - by Bioz Stars, 2026-02
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il 4  (Cusabio)
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Cusabio il 4
Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and <t>Il4</t> mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Il 4, supplied by Cusabio, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/il 4/product/Cusabio
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il 4 - by Bioz Stars, 2026-02
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il4  (Miltenyi Biotec)
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Miltenyi Biotec il4
Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and <t>Il4</t> mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).
Il4, supplied by Miltenyi Biotec, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/il4/product/Miltenyi Biotec
Average 95 stars, based on 1 article reviews
il4 - by Bioz Stars, 2026-02
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Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).

Journal: bioRxiv

Article Title: Lactate treatment improves brain biochemistry and cognitive function in transgenic Alzheimer’s and wild-type mice

doi: 10.64898/2026.01.28.702254

Figure Lengend Snippet: Early-lactate administration (1.1–2.3 months at the start, 4.0–5.0 months at the endpoint) reduced pro-inflammatory Il1b mRNA levels in Tg mice and increased anti-inflammatory Il13 and Il4 mRNA levels in WT mice, suggesting a protective effect. Relative gene expression was quantified by RT-qPCR using the 2 ⁻ΔΔCt method. Data are presented as individual data points, with males and females combined. (a) Il1b mRNA was significantly downregulated in lactate-treated Tg mice ( n = 7, p = 0.026, d = 1.30) compared to Tg controls ( n = 7). (b) Il4 mRNA was significantly upregulated in lactate-treated WT mice ( n = 3) compared to WT vehicle controls ( n = 5, p = 0.036, d = 1.66). A similar trend was observed in Tg mice, but the difference was not statistically significant. (c) Il13 mRNA was significantly increased in lactate-treated WT mice ( n = 2) compared to WT vehicle controls ( n = 3, p = 0.008, d = 3.08). Statistical analyses were performed using one-way ANOVA followed by Fisher’s least significant difference test (LSD). Results are displayed as mean ± standard deviation (SD).

Article Snippet: Genes of interest, including Bdnf (Mm01334042_m1), Hcar1 (Mm00558586_s1), Igf1 (Mm00439560_m1), Il1b (Mm00434228_m1), Il4 (Mm00445259_m1), Il13 (Mm00434204_m1), Slc16a7 (Mct2) (Mm00441442_m1), Vegfa (Mm00437306_m1), were assessed.

Techniques: Gene Expression, Quantitative RT-PCR, Standard Deviation